Repair, Reorganize, Regenerate: The New Frontier in Tissue Care
VEMFtherapy, also known as Biodermogenesi, is a regenerative medicine method based on the synergy between low-frequency electromagnetic fields, vacuum and low-intensity electrostimulation. It is able to repair, reorganize and regenerate biological tissues even in particularly complex situations.
Extensive scientific literature has proved that low-frequency electromagnetic fields are able to facilitate the reparative processes of skin lesions [01], [02], reducing healing and restructuring times of the skin, promoting its regeneration [03], [04], [05].
The magnetic fields also support the stabilization of different cell types involved in regeneration, tissue engineering and wound healing processes [06].
The available scientific bibliography shows that the low-frequency electromagnetic fields can achieve significant improvements in restructuring of injured, traumatized or destructured tissue [07], [08], [09], leading to healing and regeneration even of permanent injuries [10], [11], [12].
The reparative activity is combined with a strong action against fibrosis which are progressively reduced both in pathologies of mainly aesthetic value such as cellulite [13] and in significant pathologies such as hypertrophic scars and keloids combined with disabling fibrosis [14]. Sometimes, fibrosis resulted in scarring can lead to chronic tissue inflammation, pain and reduced motility.
Dalla fibrosi alla guarigione: una nuova possibilità terapeutica
The vacuum was also found useful in reducing fibrosis due to cellulite and scarring [15] [16], provided that it is used with negative pressures between 8 and 16 hundredths of atmosphere. In other cases, the vacuum has been proven to be an effective pain relief therapy [17].
The fields of application of VEMFtherapy
VEMFtherapy is efficiently and safely used
in the treatment of the following pathologies:
Scars
VEMFtherapy showed a particular efficacy in the scar treatment, starting from the first study carried out by the Plastic & Reconstructive Surgery team of University of Pavia [18], targeting post-surgical and burn scars.
The aesthetic improvement in all patients joined up with significant benefits for those also burdened by chronic pain and reduced mobility caused by their scars. According to the patients, the scars were significantly influencing their lives and thanks to VEMFtherapy the chronic difficulties which were affecting them are now reduced (effect of scars on the life quality equal to 6.8 out of 10, decreased to 1.8 after the course of treatment).
The bibliography on facial scars is particularly rich. A study dedicated to such scars [19] due to trauma, abrasion and surgery showed that VEMFtherapy not only heals the lesion, which sometimes regenerates significantly, getting tanned with sun exposure, but also prevents its degeneration caused
by the loss of hydration typical of scars [20].
In fact, all the scars show a hydration deficit with an average value of more than 22% less than the adjacent healthy skin. After the cycle of VEMFtherapy sessions, the difference of the hydration level between scars and healthy skin was reduced to 1%.
VEMFtherapy also proved efficacy in the treatment of chemical burns [21], as shown by the experience of Filomena Lamberti, the first woman to be attacked with acid in Italy. The patient was taken into care 12 years after the aggression that destroyed all the skin on her face and neck and compelled her to undergo 30 reconstructive plastic surgeries.
Before VEMFtherapy, the patient was complaining of neck and head pain caused by heavy fibrosis, loss of sensitivity and reduced head mobility. After 15 weekly sessions, the patient was able to move her head freely, forgot the pain that she was often feeling and recovered the full sensitivity of her facial skin so much so she “feels the wind on her skin after more than 10 years”.
Similarly, a patient with first and second-degree burns on his face with hyperpigmented (dark) and hypopigmented (light) spots removed the burn damages and recovered his normal skin colour [22].
On the complex situation of major burns, VEMFtherapy was able to regenerate the skin and muscles of patients with 80% of their body covered by third-degree burns [23], letting them to witness a major improvement in their quality of life.
All the treated patients had an evident aesthetic improvement of their scars with total absence of side effects.
Stretch Marks
VEMFtherapy is probably the best available treatment for the stretch marks. In fact, it is the only method that activates the systematic tanning by simple sun exposure and the only method which is not observed any side effects or discomfort, even minimal, for patients.
The therapy regenerates stretch marks reorganizing the basement membrane and producing new melanocytes which will support the tanning, but also new type III collagen, the one that typical of child skin, elastic fibres and capillaries. Stretch marks are filled progressively, shows attenuation to the touch and then to the eye thanks to tanning.
A specific study showed that a tan is achieved even in cases of stretch marks older than 20 years [24].
All this is well documented by various published clinical studies. The first was carried out by the School of Dermatology of the University of Pisa [25] which demonstrated efficacy and safety of VEMFtherapy on 19 patients of all phototypes, validated with ultrasounds and biopsies.
A subsequent study performed on 60 patients, all documented with biopsy and histochemical evaluation, showed an effective regeneration of the striae [26]. Later, the multicentre study that turns out to be the most important one in stretch mark therapy [27], involving Italian, Spanish, British and Turkish doctors, concerning 917 patients and 1,264 body areas treated, confirmed the efficacy on all patients, 85% of whom declared themselves to be very or extremely satisfied with the improvements achieved.
Finally, researchers from the Universities of Barcelona and Verona demonstrated the efficacy and safety of VEMFtherapy against post-pregnancy stretch marks [28].
Anti-aging
Also, in the area of skin aging, VEMFtherapy has proven to be effective and safe for the patient promoting a significant skin rejuvenation of face and neck, normalising its pH and sebum production and increasing hydration by more than 30% [29].
In the same clinical study involving 217 patients, 55 of whom were over 61 years old, significant improvements were achieved, remaining stable in the vast majority of patients for at least six months.
New Fields of Application
VEMFtherapy is enlarging the fields of clinical research in other pathologies that will be the subject of studies and subsequent publications.
Dupuytren’s Contracture
First study [30] showed that patients burdened by Dupuytren’s Contracture caused by scars on the palm of the hand can recover complete extension and mobility of the fingers and normal hand strength.
The improvement was documented echographically, with a clear reduction of the initial fibrosis, and with an infrared camera that demonstrated the recovery of microcirculation on the contracted fingers and the entire hand in question [30].
Main Characteristics of VEMFtherapy
Effective in at least 95% of patients treated
Effective and safe for all skin phototypes
Without side effects
Zero downtime
Extremely pleasant and relaxing
No lifestyle limitations imposed on patients in any way
No limitations of sun exposure
Bibliographic References
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[14] Hernández-Bule, María Luisa; Toledano-Macías, Elena; Pérez-González, Luis Alfonso; Martínez-Pascual, María Antonia; Fernández-Guarino, Montserrat (2023-07-01). “Anti-Fibrotic Effects of RF Electric Currents”. International Journal of Molecular Sciences. 24 (13): 10986. doi:10.3390/ijms241310986. ISSN 1422-0067. PMC 10341950. PMID 37446165.
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[20] Zhao, Jingling et al. Epidermal HMGB1 Activates Dermal Fibroblasts and Causes Hypertrophic Scar Formation in Reduced Hydration. Journal of Investigative Dermatology, Volume 138, Issue 11, 2322 – 2332
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